Process Engineering for Pharma Professionals

This is intended to provide visibility to the non-engineers on how they can leverage chemical engineering approaches to meet their process needs.

Reach out how we can tailor per your organization's needs, including real world case studies. It can range from few hours (spanning a few days to weeks) of lectures cum practical workshop sessions.

This is based on training offered to non-engineering professionals in pharma spaces and a 2-credit course developed for graduate level students in Pharmacy at NIPER, Hyderabad, India

Expand this space to see below the details of potential topics that can be covered

1. Basics of process calculations:

Momentum, mass and energy balances;

Concepts of control volumes;

2. Basics of transport phenomena:

Fluid mechanics; heat and mass transfer; relevant properties and modes

Conduction, Convection and Radiation

Diffusion, Convection and Dispersion;

Heat and mass transfer coefficients

Relative time scales of processes;

Concepts of non-dimensional numbers;

Flow through packed beds

3. Basic concepts of fluid rheology

Newtonian, and Non-Newtonian fluids

Emulsions and suspensions- Impact of shear

4. Basics of chemical engineering thermodynamics

Vapor/liquid and liquid/liquid equilibria- concepts of chemical potential

5. Basics of granular flow/ powder technology

Powder characterization

Powder rheology

6. Basics of reaction engineering

PFRs and CSTRs

Residence time distributions

Reactions in Series and Parallel

7. Unit operations/ processes in the pharmaceutical industry

Mixing:

Agitators/ Mixing vessels

High shear mixers

Homogenization

Size Reduction

Micronization

Milling (Bead milling)

Homogenization (High shear, High pressure, Microfluidizer)

Blending

Drying

ANFD

Lyophilization

Solids Blending

Reactions

-In conjunction with transport phenomena:

-Specific processes: ex: Nitration, Hydrogenation, Halogenation

Distillation

Extraction

Filtration

Chromatography

8. Safety aspects

- Hazard analysis and quantification

- Dust explosions

- Leveraging reaction engineering principles

9. Introduction to mathematical modeling of chemical processes

10. Introduction to engineering based scale-up of pharma processes

- Among other things, we will cover here: Safety concerns, and impurity profile control during scale-up

11. Batch And Continuous Processes

- Different operation in the continuous mode (like reactions, mixing, micro-reactors, emulsification, etc) and compare how they fare with similar batch operations

Effectively Leverage the Power of Engineering Simulation For Your Product Development and Scale-up

Expand this space to see below the details of potential topics that can be covered

Technical teams in corporate settings are under immense pressure to deliver products at large scales. These can be specialty products like those in pharma, nano-inks, -suspensions, -composites, polymers, etc, where the high value of the offering is at risk if there are delays in launching the product. Challenges can be in terms of

  • what are those 'necessary' experiments to be conducted


  • how can we ensure what I do in the lab makes sense when I go the plant scale or at the customer


  • how can we get consistent product when I change from site-site


  • what are those right 'simulations' to do and how can I make sense of those outputs for my needs

Perhaps we can partner with your teams to make sense out of this situation together and device a success strategy! We can define success criteria and can help you succeed